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Monthly Archives: September 2015

New article on hormones interacting with neurotransmitter receptors in PLOS ONE

ReseT3 interactions with GABA(A) receptorarch from our collaboration with Dr. Joe Martin’s group here at Rutgers-Camden is now published in PLOS ONE: “Interactions of  L-3,5,3′-triiodothyronine, Allopregnanolone, and Ivermectin with the GABA(A) receptor: Evidence for Overlapping Intersubunit Binding Modes” by T. Westergard, R. Salari, J. V. Martin, and G. Brannigan.

In this paper, we use experimental and computational methods to investigate the likelihood that thyroid hormone T3 and the neurosteroid allopregnanolone bind to intersubunit binding site(s) in the transmembrane domain of the GABA(A) receptor.  We also use results from Molecular Dynamics Simulation to propose an explanation for why mutagenesis studies are so frequently inconclusive for GABA(A) pharmacology.

Welcome, Sreelekha Revur!

Sreelekha (Lekha) Revur, a Masters student in Computational and Integrative Biology, has joined the group.  Lekha is currently deciding among several cool projects!