We were thrilled to hear that Group Alumni Shashank Chavali (MS 2016) just defended his PhD dissertation “Use of Lab-Evolved Proteins to Guide Development of Inhibitors that Target HIV-1 TAR RNA” at the University of Rochester. He will be moving on to a joint postdoc between the Sindelar and the De La Cruz labs at Yale University, studying motor proteins. Congratulations Dr. Chavali!
Liam’s paper “Spontaneous lipid binding to the nicotinic acetylcholine receptor in a native membrane” has been published! It is a contribution to the JCP Special Collection in Honor of Women in Chemical Physics and Physical Chemistry, and is also the culmination of Liam‘s doctoral research, so it is particularly special to me! This paper uses coarse-grained molecular dynamics and a metric for lipid binding affinities to provide quantitative ranking of specific lipid binding in a very complex membrane. It builds on his previous papers identifying specifically-bound lipids in model membranes.